CAR T-Cell Therapy: High Response Rates, High Toxicity Rates
CAR T-cell therapy has drastically changed the treatment landscape of patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) – a patient population that traditionally has been difficult to treat and had poor outcomes.
“CAR T-cell represents new treatment for diffuse large B-cell lymphoma in the relapsed/refractory setting,” said Andrew D. Zelenetz, MD, PhD, medical oncologist and medical director of quality informatics at Memorial Sloan Kettering Cancer Center. “As a result, it’s been included in the NCCN guidelines for transformed follicular lymphoma, transformed marginal zone lymphoma, and for diffuse large B-cell lymphoma, as well as refractory diffuse large B-cell lymphoma.”
Zelenetz recently discussed CAR T-cell therapy for this patient population at the NCCN 2020 Virtual Congress on Hematologic Malignancies.