Tag: PD-L1

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Enhancing antitumor immunity through checkpoint blockade as a therapeutic strate...

  Sep 08 2020 Tagged ICI, NHL, TCL, PD-1, PD-L1

The majority of historical therapies for managing T-cell lymphomas (TCLs) have consisted of T-cell–depleting strategies. Unfortunately, these forms of therapies can hamper the ability to mount effective antitumor immune responses. Recently, the use of checkpoint inhibitors has revolutionized the therapy of solid and hematologic malignancies.

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Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the eff...

  Aug 24 2020 Tagged ICI, PD-L1

Immunotherapies that target programmed cell death protein 1 (PD-1) and its ligand PD-L1 as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) have shown impressive clinical outcomes for multiple tumours.

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