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CAR T-Cell Research Surges
Research on chimeric antigen receptor (CAR) T-cell therapies has exploded since the first such treatment received approval in 2017. Hundreds of trials are under way, 3 therapies for hematologic malignancies are on the market, and 2 new products may receive FDA approval in the next several months, including a BCMA–directed therapy that is poised to help transform treatment of multiple myeloma (MM).
Bispecific anti-CD20 and anti-CD19 CAR T Cell Therapy Shows Efficacy in B Cell M...
Nirav N. Shah, MD, an associate professor at the Medical College of Wisconsin, discusses bispecific anti-CD20 and anti-CD19 chimeric antigen receptor (CAR) T cells in a phase 1 dose escalation and expansion trial (NCT03019055) for relapsed B cell malignancies.
Unanswered Questions Remain in DLBCL With Use of CAR T-Cell Therapies
In an interview with Targeted Oncology, Caron Jacobson, MD, discussed the data supporting use of CAR T-cell therapy as treatment of patients with diffuse large B-cell lymphoma and some of the remaining questions in this space that need to be addressed as these cellular therapies advanced forward in the field.
CRS in CAR-T course freely available on the EHA Campus
The CRS in CAR-T module, part of the 8-course EHA Campus program dedicated to CAR-T cells, is now freely accessible by everyone - even non-EHA members. The course covers all aspects of Cytokine Release Syndrome (CRS), from pathophysiology to appropriate management. As this main complication of CAR-T cell therapy requires a multidisciplinary approach (including non-hematologists like intensivists, cardiologists, and neurologists whose educational needs are addressed in this course), EHA has made this module accessible by everyone.
Off-the-Shelf CAR T-Cell Products Show Potential in DLBCL
Loretta J. Nastoupil, MD, an assistant professor in the Department of Lymphoma/Myeloma at The University of Texas MD Anderson Cancer Center, discusses the use of off-the-shelf chimeric antigen receptor (CAR) T-cell products for the treatment of patients with diffuse large B-cell lymphoma (DLBCL) and other cancers.
2020 CRI Virtual Immunotherapy Patient Summit: How immunotherapy works against c...
Immunotherapy is transforming treatment for many cancers and shows incredible promise for the future of all cancer care. But what is immunotherapy, and how does it work?
New approach to fighting cancer could reduce costs and side effects
UniSA’s Future Industries Institute Ph.D. student Mona Elsemary has developed a microfluidic approach to purify CAR T-cells, the bioengineered immune cells that are the basis of groundbreaking cellular immunotherapy—a transformative cancer therapy that harnesses the power of a patient’s immune system to fight their cancer.
Tecartus Recommended for EU Approval as CAR T-cell Therapy for Mantle Cell Lymph...
A committee of the European Medicines Agency (EMA) has recommended the conditional approval of Tecartus (brexucabtagene autoleucel) for the treatment of adults with relapsed or refractory mantle cell lymphoma (MCL).
Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off...
NextGen CARs: the race is on
In this issue of Blood, Tong et al present the preclinical and clinical development of an optimized, bivalent tandem CD20/CD19 chimeric antigen receptor (CAR) construct (see figure). Preclinically, they demonstrated dual-antigen specificity, enhanced immune synapse formation, and superior antitumor activity in vitro and in vivo in a murine xenograft model compared with alternative constructs generated from the same 2 single-chain variable fragment (scFv) regions derived from Leu-16 (anti-CD20) and FMC63 (anti-CD19) murine monoclonal antibodie.