Archive: December 29 2020

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Patient Resource: Comparing CAR-NK and CAR T-Cell Therapies

How Do Chimeric Antigen Receptor (CAR) Therapies Differ? Dr. Katy Rezvani, Chief, Section of Cellular Therapy, Department of Stem Cell Transplantation & Cellular Therapy, MD Anderson Cancer Center joins Patient Power Co-founder Andrew Schorr to explain the difference between the two new cell therapies and what this innovation means for ALL, CLL, and NHL patients.

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How is CT053 different from other BCMA-directed CAR T-cell therapies?

CT053 consists of autologous T cells genetically modified with a CAR incorporating a fully human BCMA-specific single-chain fragment variant, a 4-1BB intracellular domain, and a CD3 intracellular signaling region. The advantage over other CAR T-cell therapies is that it has a shorter manufacturing time, of 8–10 days, which allows a shorter interval between apheresis and infusion. Learn about the results of an ongoing phase I/II trial evaluating the safety and efficacy of CT053 in patients with relapsed/refractory multiple myeloma.

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Iodine apamistamab conditioning led to 100% bone marrow transplant rate and engr...

  Dec 29 2020 Tagged AML, mAbs

Treatment with iodine (131I) apamistamab (Iomab-B) conditioning led to a 100% bone marrow transplant rate and engraftment in patients with active relapsed/refractory acute myeloid leukemia who are older than 55 years old, according to results of a single ad hoc interim analysis of the phase 3 SIERRA study.

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